When you try microdosing for the first time, take a day off from work and social commitments. It will give you a chance to observe and notice any unusual effects before microdosing in a more public situation.
Be vigilant in observing the effects of microdosing on the two days between microdoses. Many people perceive increased feelings of flow, creativity, and energy the day after they microdose, as well as the day of microdosing.
Microdosing 4-ACO-DMT every day is not recommended. Psychedelics like 4-ACO-DMT produce a tolerance, even with microdoses, so you might see diminishing returns after a few days. This is why Dr. Fadiman suggested leaving a couple of days between each dose.